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KMID : 0387820180250020170
Clinical Pediatric Hematology-Oncology
2018 Volume.25 No. 2 p.170 ~ p.174
Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report
Hong Hyun-Jung

Cho Young-Hye
Lim Jae-Young
Yeom Jung-Sook
Park Ji-Sook
Park Eun-Sil
Seo Ji-Hyun
Woo Hyang-Ok
Youn Hee-Shang
Abstract
Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic anemia caused by cytomegalovirus infection developed in an immune competent 9-year-old girl. The patient¡¯s hemoglobin level was 4.8 g/dL on the day of admission. The diagnosis was achieved by exclusion of other causes of hemolytic anemia and serological evidence of recent CMV infection. The patient was successfully treated with anti-viral agents and steroids resulting in recovery from anemia. Clinicians should consider cytomegalovirus infection in the differential diagnosis of hemolytic anemia in pediatric patients.
KEYWORD
Hemolytic anemia, Cytomegalovirus
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